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  • Omega-3s in Fish & AMD; Retinal Cells & Glaucoma Detection

    Highlighted research, December’s Ophthalmology journal

    SAN FRANCISCO, CA– Seniors interested in lifestyle choices that help protect vision will be encouraged by a new Johns Hopkins School of Medicine study, and people concerned about glaucoma can take heart from work on early detection by the University of Miami Miller School of Medicine. Both studies are published in the December issue of Ophthalmology, the journal of the American Academy of Ophthalmology.

    Evidence for Eye-Protective Effects of Omega-3-Rich Fish, Shellfish
    Researchers at Wilmer Eye Institute, Johns Hopkins School of Medicine, wanted to know whether a reduced risk of age-related macular degeneration AMD would be found in a population of older people for whom fish and shellfish were a normal part of the diet, since some fish are good sources of omega-3 fatty acids. A diet rich in omega-3s probably protects against advanced AMD, the leading cause of blindness in whites in the United States, according to the Age-Related Eye Disease Study AREDS and other recent studies. High concentrations of omega-3s have been found in the eye's retina, and evidence is mounting that the nutrient may be essential to eye health. The new research, led by Sheila K. West, PhD, was part of the Salisbury Eye Evaluation SEE study.

    Food intake information with details on fish and shellfish consumed was collected over one year using a validated questionnaire for 2,391 participants aged 65 to 84 years who lived along Maryland's Eastern Shore. After completion of the diet assessment process, participants were evaluated for AMD. Those with no AMD were classified as controls 1,942 persons, 227 had early AMD, 153 had intermediate-stage disease, and 68 had advanced AMD. The advanced AMD group exhibited either neovascularization abnormal blood vessel growth and bleeding or a condition called geographic atrophy in the macular area of the eye's retina. Both conditions can result in blindness or severe vision loss.

    "While participants in all groups, including controls, averaged at least one serving of fish or shellfish per week, those who had advanced AMD were significantly less likely to consume high omega-3 fish and seafood," Dr. West said. "Our study corroborates earlier findings that eating omega-3-rich fish and shellfish may protect against advanced AMD."

    The study also looked at whether dietary zinc from crab and oyster consumption impacted the risk of advanced AMD, but no significant relationship was found. Zinc is also considered protective against AMD and is included in the AREDS-recommended AMD-vitamin/nutrient supplement. The researchers speculate that no effect was seen because the levels of zinc obtained from seafood/fish were low compared to supplement levels.

    A side note: fish and shellfish were part of the normal diet of the study population, rather than deliberate, health-related choices. The links between fish consumption, omega-3s and healthy lifestyles were not widely known in the early 1990s when the dietary survey was conducted. In fact, some of the study participants who consumed the most seafood were also smokers and/or overweight, two factors usually associated with AMD and other health risks.

    Retinal Nerve Function May be Key to Early Glaucoma Detection
    Catching glaucoma as early as possible–before it destroys the optic nerve–is vital to preventing vision loss. Now a research team at Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, has shown that a test that measures the functionality of the eye's retinal nerve cells may be a key to early detection. Eventually, the test may also help evaluate how well glaucoma treatments are working.

    The research, led by Mitra Sehi, PhD, and David Greenfield, MD, was based on the knowledge that retinal ganglion cells RGCs become dysfunctional as glaucoma progresses and that such changes can be measured using the pattern electroretinogram optimized for glaucoma screening PERGLA. PERGLA measures the electrical activity of a patient's retina as he or she views an alternating pattern of black and white lines. The retinal area in the back of the eye receives images and transmits them to the optic nerve.  Other studies had shown that abnormal changes in RGCs begin near the outset of glaucoma development, so PERGLA could potentially serve as a non-invasive early detection tool.

    The Bascom Palmer study included 47 patients 47 eyes in whom intraocular pressure IOP could not be controlled with medication and who therefore had surgery to prevent optic nerve damage. All patients had two PERGLA evaluations as well as complete ocular exams, optic nerve assessment, and blood pressure measurement, one before surgery and one at three months post surgery. IOP and PERGLA measurements of the patients' fellow, non-glaucomatous, non-treated eyes were stable before and after surgeries. The surgeries improved fluid drainage in the eyes to reduce IOP; 34 eyes had trabeculectomy and 13 had glaucoma drainage implants.

    PERGLA results showed that RGC dysfunction was reversed and IOP was reduced in all patients following surgery. The patients' central visual field tests improved, as well.  Dr. Sehi says these results should be interpreted cautiously until confirmed by larger studies. She calls for longitudinal studies to clarify the relationship between reduced IOP and increased RGC response and to further investigate PERGLA assessment of RGC dysfunction as a biomarker for glaucoma.

    Eds: Full texts of the studies are available from the Academy’s media relations department.

    About the American Academy of Ophthalmology
    AAO is the world's largest association of eye physicians and surgeons—Eye M.D.s—with more than 29,000 members worldwide.  Eye health care is provided by the three “O’s” – opticians, optometrists and ophthalmologists. It is the ophthalmologist, or Eye M.D., who can treat it all: eye diseases and injuries, and perform eye surgery. To find an Eye M.D. in your area, visit the Academy's Web site at