2020–2021 BCSC Basic and Clinical Science Course™
4 Ophthalmic Pathology and Intraocular Tumors
Part I: Ophthalmic Pathology
Chapter 11: Retina and Retinal Pigment Epithelium
Polypoidal Choroidal Vasculopathy
Polypoidal choroidal vasculopathy, previously called posterior uveal bleeding syndrome and multiple recurrent serosanguineous RPE detachments, is a disorder in which dilated, thin-walled vascular channels (Figs 11-36, 11-37) are interposed between the RPE and the outer aspect of Bruch membrane. Associated choroidal neovascularization is often present in these lesions, as observed in several histologic specimens. See BCSC Section 12, Retina and Vitreous, for more information on this condition.
Figure 11-35 Choroidal neovascularization. A, Choroidal neovascular membranes (CNVMs) located between the inner (arrow) and outer (arrowhead) layers of Bruch membrane (sub-RPE; type 1 CNVM). Note the loss of overlying photoreceptor inner and outer segments, the RPE hyperplasia, and the PAS-positive basal laminar deposit (arrow).B, Surgically excised CNVM (subretinal, type 2) composed of fibrovascular tissue (asterisk) that is lined externally by RPE (arrow) with adherent photoreceptor outer segments (arrowhead). Schematic illustrations of CNVM types 1 (C), 2 (D), and 3 (E).
(Parts A and B courtesy of Robert H. Rosa Jr, MD. Illustrations by Cyndie C. H. Wooley.)
Excerpted from BCSC 2020-2021 series: Section 4 - Ophthalmic Pathology and Intraocular Tumors. For more information and to purchase the entire series, please visit https://www.aao.org/bcsc.