In this presentation from the Academy's Maintenance of Certification (MOC) Exam Review Course, Dr. Russell Read discusses treatment guidelines for systemic therapy in noninfectious ocular inflammatory disease, cycloplegics, nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, methotrexate, azathioprine, mycophenolate, alkylating agents such as cyclophosphamide and chlorambucil, cyclosporine, and biologic response modifiers.