Intraoperative floppy iris syndrome (IFIS) continues to challenge cataract surgeons. This video discusses multiple different surgical methods in detail, with the goal of arming surgeons with a range of complimentary strategies. These include intracameral alpha agonists, ophthalmic viscosurgical device strategies, phaco techniques, iris retractors, and pupil expansion devices, including the Malyugin ring. This course also reviews what is known about the pharmacologic basis and mechanism of IFIS.  The aim of this course is to update anterior segment surgeons on the latest clinical information about benign hyperstatic hypertrophy pharmacology and the preoperative and intraoperative management of IFIS.