RNFL loss linked to MS-related inflammation in eyes without optic neuritis

The results of this study indicate a strong association between temporal retinal nerve fiber layer (RNFL) loss and multiple sclerosis-related inflammation within the optic radiation.

The authors used OCT to compare temporal RNFL thickness in 53 patients with relapsing-remitting multiple sclerosis and no history of optic neuritis and 50 age- and sex-matched controls.

Temporal RNFL thickness was significantly reduced in multiple sclerosis patients and was associated with reduced low-contrast visual acuity in this group. The investigators detected lesions within the optic radiation in the majority of patients. Thinning of the temporal RNFL was significantly associated with optic radiation lesion volume.