In this presentation from Glaucoma Subspecialty Day 2022, Dr. Claude Burgoyne focuses on the detection of early glaucoma with optical coherence tomography (OCT). The discussion includes OCT optic nerve head (ONH)/retinal nerve fiber layer (RNFL) parameters and reports from different OCT platforms, interpretation of OCT ONH/RNFL scans, use and interpretation of macular OCT for detecting glaucoma, comparison of ONH biomicroscopy and OCT ONH/RNFL analysis, utility of OCT in high myopia, and discrimination of glaucomatous structural damage from myopic anomalies and/or degeneration.