In this presentation from Glaucoma Subspecialty Day 2022, Dr. Amanda Henderson provides an update on optic neuritis in patients with multiple sclerosis (MS) and other demyelinating diseases. She discusses typical and atypical presentations of optic neuritis and how an atypical presentation changes patient management. This includes a review of diagnostic evaluation methods, including magnetic resonance imaging and serum testing, along with treatment options in the acute and chronic settings for MS, myelin oligodendrocyte glycoprotein immunoglobulin G-associated disorder (MOGAD), and neuromyelitis optica spectrum disorder (NMOSD).