2020–2021 BCSC Basic and Clinical Science Course™
12 Retina and Vitreous
Part II: Disorders of the Retina and Vitreous
Chapter 04: Age-Related Macular Degeneration and Other Causes of Choroidal Neovascularization
Other Causes of Choroidal Neovascularization
Idiopathic CNV and Miscellaneous Causes of CNV
CNV may complicate any one of the disorders known to damage Bruch membrane, including inflammatory chorioretinopathies, choroidal neoplasms, traumatic choroidal rupture, optic nerve head abnormalities, and others (Table 4-5). It may also develop in eyes with no apparent risk factors or predisposing lesions (eg, idiopathic CNV). As in other forms of CNV, anti-VEGF therapies have become the treatment of choice.
Figure 4-17 Pathologic myopia. A, Color fundus photograph of the right eye demonstrates myopic macular degeneration with pigment mottling and lacquer cracks centrally and geographic atrophy in the inferonasal macula. Extensive peripapillary atrophy of the RPE is also present. The small, round hemorrhage in the superior macula is not associated with CNV membrane. B, SD-OCT image of a patient’s left eye with pathologic myopia shows a high-grade posterior staphyloma associated with myopic macular schisis.
(Courtesy of David Sarraf, MD.)
Heier JS, Brown D, Ciulla T, et al. Ranibizumab for choroidal neovascularization secondary to causes other than age-related macular degeneration: a phase I clinical trial. Ophthalmology. 2011;118(1):111–118.
Kang HM, Koh HJ. Intravitreal anti–vascular endothelial growth factor therapy versus photodynamic therapy for idiopathic choroidal neovascularization. Am J Ophthalmol. 2013; 155(4):713–719.
Table 4-5 Conditions Associated with Choroidal Neovascularization
Excerpted from BCSC 2020-2021 series: Section 10 - Glaucoma. For more information and to purchase the entire series, please visit https://www.aao.org/bcsc.