Hyperglycemia May Promote Monosomy-3 in Uveal Melanoma

Drs. Lauren Dalvin and Aysegül Tura discuss a newly discovered link between hyperglycemia, monosomy-3, and uveal melanoma at ARVO 2023. In lab studies, hyperglycemia was shown to be associated with a relocation of chromosome 3 that resulted in chromosome 3 being repositioned closer to chromosome 6 during early cell division. This alteration led to missegregation and an increase in the coexistence of two aberrations, monosomy-3 and a gain of chromosome 6P. Drs. Dalvin and Tura talk about what these findings may mean for patients with uveal melanoma and diabetes and about directions for further research. 

Financial Disclosures: Dr. Lauren Dalvin discloses financial relationships with the Leonard and Mary Lou Hoeft Career Development Award Fund, National Cancer Institute, and National Center for Advancing Translational Science (Grant Support). Dr. Aysegül Tura discloses a financial relationship with Novartis Pharma AG (Financial Support).