Noninfectious uveitis is often associated with underlying systemic conditions. For this reason, the specific diagnosis is of critical importance so that therapy is initiated when appropriate, for both ocular and systemic inflammatory disease. A thorough understanding of immunomodulatory agents is also paramount for the successful management of patients with noninfectious uveitis. This collection of content reviews the diagnostic hallmarks, traditional therapies, and newer lines of therapeutic agents for noninfectious uveitis.