• Courtesy of Patricia Chévez-Barrios, MD.
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    Ocular Pathology/Oncology

    Schematic representation of the progression of OSSN. The first panel represents normal epithelium with basement membrane (pink line). In CIN, a portion of the epithelium is replaced with dysplastic cells. Carcinoma in situ is the complete replacement of epithelium by dysplastic cells, with the basement membrane still intact. In invasive squamous cell carcinoma, note the invasion through the basement membrane into the stroma.