• Written By: Nancy Thomas, MD
    Comprehensive Ophthalmology, Retina/Vitreous

    Researchers used optical coherence tomography to examine 21 patients (21 eyes) with vascularized pigment epithelial detachment (PED) who developed retinal pigment epithelial tears after intravitreal bevacizumab injection. A random selection of 78 vascularized PED eyes that did not develop tears after injection served as controls. Multivariate analysis showed elevated pre-injection PED height to be a significant independent risk factor for tear development (odds ratio = 0.995; P<0.001), particularly when it is greater than 400 µm and in the presence of increased subretinal fluid.  Other risk factors were increased volume index (P=0.001), subretinal fluid (P=0.002) and total macular volume (P=0.04).