Topical prostaglandin analogues linked to a modest increase in CCT thinning

This analysis of longitudinal data from the Ocular Hypertension Study found that the rate of  central corneal thickness decrease over 3.8 years is comparable to the cross-sectional age differences reported in the OHTS at the first measurement (0.6 μm/year) and comparable to other cross-sectional studies. Subgroup analyses suggest that participants treated only with topical prostaglandin analogues between the two CCT measurements had a greater rate of decrease per year than participants treated only with topical β-blockers. The authors note that the modest age- and drug-related rates of thinning they describe are unlikely to influence tonometry or clinical decision-making over the short to intermediate term.

References

Ophthalmology, September 2008