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  • Illustration by Cyndie C.H. Wooley.
    File Size: 640 KB
    Comprehensive Ophthalmology

    Comparison of sporadic retinoblastoma (A), where 2 independent mutations (“hits”) in the RB1 gene occur in a somatic cell, with hereditary retinoblastoma (B), where a germline mutation is present in every cell and second mutations can arise in multiple cells, leading to multiple tumors.