Radiation retinopathy. Images of an eye that has undergone plaque brachytherapy for treatment of choroidal melanoma. The melanoma can be seen nasally, obscuring part of the optic nerve head. Typical radiation retinopathy changes are apparent. A, In the fundus photograph, cotton-wool spots, exudates (“hard” exudates), and intraretinal blot hemorrhages are visible. B, The fluorescein angiography image shows microvascular abnormalities (representative of capillary nonperfusion) superior to the fovea and adjacent to an enlarged foveal avascular zone. Additional areas of nonperfusion are noted in the macula and near periphery.