A, Fundus photograph of the right eye of a 47-year-old woman with sickle cell–hemoglobin C (HbSC) disease and 20/20 vision. B, FA is unremarkable. C, Top row: OCT angiography (OCTA) of the superficial and deep capillary plexus shows an enlarged foveal avascular zone (FAZ) that is especially prominent in the superficial, pruned capillaries. Middle row: Cross-sectional OCT with flow overlay, showing widened foveal depression, vitreomacular adhesion, and expanded vascular FAZ bound aries. Bottom row: Superficial vessel density (right) and inner retinal thickness (left) maps. Left image shows central thinning consistent with an enlarged FAZ, while the capillary density map highlights decreased density in areas outside the FAZ (pseudocolored in deeper shades of blue).