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    Retina/Vitreous

    Stargardt disease. a. A bull’s-eye pattern of central atrophy with surrounding retinal pigment epithelium (RPE) changes and subretinal flecks is apparent in the fundus photo of an individual with genetically confirmed ABCA4 disease. b. A “silent choroid” is seen on fluorescein angiography, which also shows window defects at the fovea and variable fluorescence of the subretinal flecks. c. Fundus autofluorescence shows central hypoautofluorescence corresponding to RPE atrophy, with hyperautofluorescence of the subretinal flecks. d. Central atrophy is present on optical coherence tomography through the fovea. e. Subretinal flecks can be seen at the superior edge of the atrophic zone.