Autologous Retinal Transplant for Macular Holes

In this interview from AAO 2017, Dr. Tamer Mahmoud describes his initial experience with using autologous retinal transplant for macular holes (MH). His surgical technique, which was initially published in JAMA Ophthalmology, involves harvesting an autologous neurosensory retinal free flap and positioning it over the hole to provide a scaffold and plug for closure. Dr. Mahmoud typically uses this method for patients with large (>400 microns), recurrent holes. With his technique, an impressive 99% of patients have achieved anatomic hole closure. Recovery of vision remains unpredictable, however, so Dr. Mahmoud recommends thorough counseling before surgery. Additionally, he notes that even those with limited visual recovery have reported gradual improvements with the “black void” in the center of their vision. Dr. Mahmoud’s most recent findings were published in Retina.

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