Intraocular Lymphoma Biopsy

Drs. Shilpa Desai and Chirag Shah describe a case of intraocular lymphoma in a 56-year-old patient who presented with vitritis and a leopard-spot pattern on her fundus. Though a vitreous biopsy revealed high-grade B-cell lymphoma and an MRI confirmed intracranial lymphoma, Dr. Desai cautions that this cancer is often misdiagnosed as posterior uveitis due to shared features and apparent improvement on steroid therapy. If a presumed posterior uveitis patient shows an atypical course, a biopsy is recommended. If the first biopsy is inconclusive, a second biopsy should be performed after withdrawal from steroids.

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