In this presentation from AAO 2015, Dr. Thomas J. Liesegang discusses ocular infections from herpes simplex virus (HSV), which can present in a myriad of forms including blepharitis, follicular conjunctivitis, keratitis (epithelial, stromal, and endothelial), keratouveitis, and posterior segment disease. Diagnosis can be made by patient history and slit-lamp examination, and though many aspects of the disease can masquerade as separate conditions, presentation is almost always unilateral. Severity depends on the strain of HSV (patients can acquire more than one, and the cornea can be a reservoir for latent HSV) and the immune susceptibility of the patient.